To develop a small-molecule drug, researchers spend years ... called structure-based drug design. The 3-D structure of many proteins remained unavailable, and many important proteins could not ...

Predicting a protein's structure from its amino acid sequence ... A 4 Å model will indicate what residues are on the same side of the molecule and could help in planning experiments.

This article was originally published with the title “ The Three-Dimensional Structure of a Protein Molecule ” in Scientific American Magazine Vol. 205 No. 6 (December 1961), p. 96 doi:10.1038 ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

From growth hormones to cancer drugs, small molecules play a crucial role in our health. Monitoring them is essential to ...

Scientists still needed to figure out this molecule's structure to be sure, and to understand how it worked. In 1948, Linus Pauling discovered that many proteins take the shape of an alpha helix ...

These DZBB assemblies serve as a versatile foundation for molecular ... for synthesizing proteins in cells. This evolutionary ...

“Not just the spatial structure of the protein but how it changes over time, and that seemed like a perfect match for sound as sound doesn’t even exist without time.” Usually, scientists visualize ...

Deoxyribonucleic acid (DNA) is the information-carrying molecule found in all living ... is the instructions that the cell uses to make proteins. Proteins play a big part in determining the ...