A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

An enzyme that helps clear damaged mitochondria can act as a molecular switch and potentially prevent neurons from dying.

Mutations in the PINK1 gene are the second most frequent cause of autosomal recessive parkinsonism after Parkin, and can represent a risk factor towards sporadic Parkinson's disease. The PINK1 ...

Among them, PINK1 (PTEN-induced kinase 1) and Parkin (an E3 ligase) have been found to play a key role in mediating mitophagy following acute mitochondrial damage. Mutation of PINK1 and Parkin ...