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揭示 Luminal B 型乳腺癌奥秘:PI3K-mTORC 和 Hippo 通路调控鞘脂代谢
蛋白激酶 A(PKA)、蛋白激酶 C(PKC)家族以及 p70 核糖体 S6 激酶(RPS6K)在 LBBC 中被强烈激活,而细胞周期蛋白依赖性激酶(CDKs)则受到显著抑制。磷脂酰肌醇 3 - 激酶 - 哺乳动物雷帕霉素靶蛋白复合物 1(PI3K-mTORC)和 Hippo 信号通路在癌症中特异性激活也备受 ...
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