In this project, we will examine the source of the myofibroblasts that play a key role in organ fibrosis. The regulation of the trafficking and differentiation of these cells by chemokines and other ...

Hepatic fibrosis ... perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver, deposition of scar molecules, vascular and organ contraction, and ...

more durable one. During their study of mouse models of liver, kidney, and lung fibrosis, the researchers found that the organs displayed very high levels of an enzyme known as MERTK. They also ...