We have also recently demonstrated that the adenosine nucleotide translocase (ANT) proteins are integral components of the mitochondrial permeability transition pore (MPTP). We have found that ...

Figure 1: Mitochondrial involvement in cell death. Mitochondria are organelles with two well-defined compartments: the matrix, surrounded by the inner membrane (IM), and the intermembrane space ...

Possible candidates for the protein that constitutes the mPTP include the voltage-dependent anion channel, adenine nucleotide transporter and the mitochondrial phosphate translocator protein.

For instance, inhibitors of MCU and stabilizers of mitochondrial permeability transition pore (mPTP) show promise in preclinical models. In this review, we emphasize the role of Ca2+mito in both ...