Instead of binding to DNA through the insertion of an α-helix into the DNA major groove — a motif which is used by the ubiquitous helix–turn–helix family of transcription factors — RHH ...

This first loop sits in the major groove and makes sequence-specific contacts for all six proteins. The number of contacts, and therefore the overall contribution to DNA binding specificity is ...

ChVLig encircles the DNA as a C-shaped protein clamp. The NTase domain binds to the broken and intact DNA strands in the major groove flanking the nick and also in the minor groove on the 3’-OH side ...

The left-handed Z-DNA double helix is held together by traditional Watson-Crick base pairs, but unlike righthanded B-DNA, which has major and minor grooves between the twists of its sugar-phosphate ...