Inspired by hepatic lobules, a novel artificial liver was developed by assembling morphological cell sheets with high accuracy in terms of cell type, density, and distribution. By simulating the ...

The puzzle Starting with mouse livers treated with carbon tetrachloride (which models acetaminophen damage), Drasdo’s team built computational models of how liver lobules regenerate after damage.

Liver cells are organized around the central veins to form hexagonal hepatic lobules that are powerhouses of liver metabolism and immune-metabolic regulators upon infection.

The left image shows hepatic tissue or lobule in a diseased state (fibrotic and inflamed); the right shows the expected state after HepaStem treatment. Making clinical strides ...