The recent findings of Waldo et al. 1 demonstrate that the fusion of the green fluorescent protein (GFP) to insoluble proteins dramatically reduces its folding ability in prokaryotic cells.

What if evolution could be simulated in a lab? At the intersection of artificial intelligence, biology, and evolutionary ...

Evolution has been fine-tuning life at the molecular level for billions of years. Proteins, the fundamental building blocks of life, have evolved through this process to perform various biological ...

Avoid fusions to the GFP fragments at the site of protein-protein interaction and consider optimizing the spacer length between the fusions and GFP fragments, if necessary. In the absence of ...

A startup founded by former Meta researchers is creating an alternative evolutionary path using the most powerful ...

It’s been trained on 771 billion unique tokens – the AI term for a unit of data – taken from databases of natural protein ...

Leveraging the power of large language models, evolutionary biologists have successfully simulated 500 million years of ...

GFP, expanding its portfolio of secondary antibodies for life science research. GFP is widely used to monitor protein ...

In a study published in Science, researchers detailed how they used advanced language models to fast-forward evolution, simulating hundreds of millions of years of genetic changes ...

Here, we use a synthetic amphiphile to modulate the membrane mechanical properties of cell-derived vesicles and probe channel activation. Using precise membrane mechanical characterization approaches ...

The model was able to predict optimized GFP sequences that had as many as seven different amino acids from the protein sequence they started with, and the best of these proteins were estimated to ...

An artificial intelligence (AI) model has simulated half a billion years of molecular evolution to design the blueprint for a ...