ERRα 促进 PCSCs 向 OXPHOS 的能量代谢转变:利用 Seahorse Extracellular Flux 分析仪检测发现,PCSCs 富集的前列腺球体相对于其贴壁亲本细胞,具有更高的氧消耗率(OCR)和 ATP 产生,同时细胞外酸化率(ECAR)降低,表明 PCSCs 更依赖 OXPHOS 供能。此外,ERRα 过表达增强了 ...
Defects in the oxidative phosphorylation (OXPHOS) system — the final biochemical pathway in the production of ATP — result in devastating, mainly multisystem diseases. The OXPHOS system is ...
The correlation between ERRα expression level and pathological grade, overall survival and cancer types: a study from a cohort of 150 patients with breast cancer.