These new bonds were only discovered in 2016, and are formed when the end of a lysine side-chain is linked to the end of a cysteine side-chain with an oxygen atom linking them together. The NOS ...

The amino acid cysteine has a chemically reactive side chain that can form bonds with another cysteine. Amino acids can also be basic, like lysine, or acidic, like glutamic acid.

The formation of buried side chain structure at the probe sites is followed by the extent of thiol-disulfide exchange during a pulse of thiol labeling reagent (either methyl methanethiosulfonate ...

When scientists expose these peptides to a chemical that reacts selectively with the sulfur atoms, the chemical forms a "staple" that connects the two cysteine side chains. Experts believe stapled ...

Stapling the peptides' side chains encourages the peptides to adopt and stay in a helix, which enables them to enter cells more easily. The helical conformation also makes it more difficult for ...

The most commonly used spin-labeling reagent, (1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)-methanethiosulfonate, contains a paramagnetic nitroxide side chain attached to a methanethiosul-fonate ...

Proteins are made of amino acid chains, or polypeptides. Amino acids have a basic backbone made of an amino group and a carboxyl group, and differ in their side-chains.

These new bonds were only discovered in 2016, and are formed when the end of a lysine side-chain is linked to the end of a cysteine side-chain with an oxygen atom linking them together. The NOS ...