这一研究性突破揭示了长期以来被认为隐藏在DNA中的“空间语法”，或有望重塑科学家们对基因调节机制的理解以及阐明在机体发育或疾病发生过程中基因突变影响基因表达背后的分子机制。转录因子是控制基因组中基因开启或关闭的特殊蛋白，其在这些代码功能发挥中扮演着至 ...

A frameshift mutation is a genetic mutation caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read. A DNA sequence is a chain of many smaller molecules called ...

Applied since the 1930s to accelerate the process of developing and selecting new valuable agronomic traits, mutation breeding uses a plant’s own genetic make-up, mimicking the natural process of ...

A nonsense mutation is a genetic mutation in a DNA sequence that results in a shorter, unfinished protein product. DNA is a chain of many smaller molecules called nucleotides. During protein ...

To artificially induce hereditary changes in plants, either physical or chemical agents are used. Ionizing radiation is a widely used physical agent to treat the seeds and other plant material of ...

In an effort to expand its cash runway beyond 12 months, Prime Medicines has signed a deal with Bristol Myers Squibb worth a ...

Tuberculosis is a confounding scourge. It’s the leading cause of death from infectious disease in the world, and yet it’s estimated that those deaths represent perhaps 5% of infections with ...

advancing PM359 into the clinic and generating preclinical data that show we can reproducibly and durably correct disease causative mutations in multiple cell types and successfully deliver Prime ...

Researchers discovered that mammals - from tigers to humans - have roughly the same number of mutations by the time they die of old age. But short-lived animals tend to burn through their ...

Mutations occur continuously and can be spontaneous. Most are caused by errors when the DNA is copied prior to cell division. They can also happen because of: ionising radiation close ionising ...

However, changes in the genome do occur. These are known as mutations. Mutations can have two results: no protein is expressed an altered protein is expressed Some mutations can affect a few bases ...