参考资料： [1] Liang et al., Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells. Cell (2024) DOI: ...

世界卫生组织数据显示，全球每年约 1930 万癌症新发病例中，1000 万人因癌离世。尽管免疫检查点抑制剂（如 PD-1 抗体）已革新癌症治疗，但仍有大量患者面临 「无响应」 或 「耐药」 难题。其中，自然杀伤细胞（NK ...

《Nature Communications》：CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly 【字体： 大 中 小 】 时间：2025年05月31日 来源：Nature Communications 14.7 ...

CRISPR-droplet sequencing, or CROP-seq, involves pooled CRISPR screens and a single-cell readout based on RNA sequencing. The method can be matched up well with base-editing techniques, ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

Some CRISPR screens may be missing cancer drug targets. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2024 / 06 / 240615010952.htm ...

Combinatorial screens. While earlier CRISPR screens focused on benchmarking CRISPR, which is the new kid on the block, against shRNA, the prior gold standard, 7,8 recent attention has focused on ...

CRISPR screens can be performed either with a pooled approach, where all the cells are in large plates, or an arrayed approach, where each well in a multiwell plate contains a different target.

Some CRISPR screens may be missing cancer drug targets. Broad Institute of MIT and Harvard. Journal Nature Communications DOI 10.1038/s41467-024-48957-z. Keywords ...

CRISPR screen identifies EIF3D as critical regulator of stem cell pluripotency maintenance. Story by Science X staff • 11h. A team of CiRA researchers has uncovered the crucial role of EIF3D—a ...