来自上海科技大学，加州大学旧金山分校，中山大学等处的研究人员发表了题为“A genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cellactivation”的文章，利用CRISPR全基因组遗传筛选，系统性地研究了T细胞激活的分子机制，绘制了人类T细胞功能的调控图谱。

该研究成果于9月28日在线发表在Nature Plants (DOI: 10.1038/nplants.2015.144)。高彩霞研究组的硕士研究生姬祥和助理研究员张华伟为该文共同第一作者。该研究得到国家自然科学基金委项目资助。 CRISPR/Cas9 转基因植物抵御 DNA 病毒侵染的示意图. 原文摘要： ...

Jennifer Doudna is an expert in CRISPR, Dr. Jill Banfield is an expert in screening through giant numbers of sequences for new CRISPR systems and I'm an expert in plants.

The emergence of CRISPR-Cas9 genome-editing tools created new opportunities for enhancing plant and crop traits in agricultural biotechnology research. Now, multiplex genome-editing (MGE) technologies ...

While CRISPR/Cas9 is an enormous step forward for plant breeding, it remains nonetheless an expensive and laborious solution, making it unfeasible for application in most plants. The recent ...

CRISPR-Cas9 based gene editing is a powerful tool which can induce heritable mutations at desired genomic loci without leaving transgenic trace in plants. Here we constructed a robust, multiplex ...

The emergence of CRISPR-Cas9 genome-editing tools created new opportunities for enhancing plant and crop traits in agricultural biotechnology research. Now, multiplex genome-editing (MGE) technologies ...

But one of the things that gives Qi hope is that before Crispr, such screening studies were only possible in a small number of model organisms—plants like rice and maize and an herbaceous ...

More information: Changtian Pan et al, Boosting plant genome editing with a versatile CRISPR-Combo system, Nature Plants (2022). DOI: /10.1038/s41477-022-01151-9, ...

Scientists have developed CRISPR-Combo, a method to edit multiple genes in plants while simultaneously changing the expression of other genes. This new tool will enable genetic engineering ...