The technology, called CRISPR-LICHT (for CRIPSR-LIneage tracing at Cellular resolution in Heterogenous Tissue), was used to determine that 25 out of 173 candidate microencephaly genes are indeed ...

CRISPR Screen Detects Functional Gene Regulation. A CRISPR-Cas9–based method probes the regulatory roles of noncoding DNA sequences. Abby Olena, PhD. Abby Olena, PhD. As a freelancer for The Scientist ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency. The research is published in the journal Science Advances.

Li M et al. Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution. Cell Rep . 2018; 24: 489–502. Doench JG.

CRISPR screen identifies new anti-inflammatory drug target. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 11 / 211111130327.htm ...

A CRISPR-based loss-of-function screen has identified host genes that are needed for SARS-CoV-2 to infect human lung cells, pointing to potential novel treatment targets for COVID-19. SARS-CoV-2 ...

Early single-cell CRISPR screen platforms suffered from one of two problems. They either: (i) required lentivirus to be prepared in an arrayed format (i.e. one well per guide RNA in the screen) or, ...

But a new CRISPR screen method developed at Scripps Research has the potential to uncover new therapeutic targets and treatments for these conditions. The method, ...

The team started with 40 million epithelial cells, using CRISPR to select cells that kept dividing uncontrollably. They were surprised to discover that a loss of TRAF3 activates signaling that in ...