Monoclonal antibodies, or mAbs, are important tools in medicine. These laboratory-made proteins are widely used in treatments ...

“Protein structure can change in the culture condition — we need to look at their ever-shifting states, not just a snapshot.” Initial images have already shown that antibody structures ...

Antibody drugs have reshaped how we treat diseases. By harnessing the immune system to destroy tumours or temper excessive inflammation in autoimmune disorders, these therapeutics have become ...

Strategies to optimize structures A detailed knowledge of antibody structure and activity now ... proof-of-concept of the clinical efficacy of new protein scaffolds with different pharmacological ...

Antibodies usually have a Y-shaped structure, and these hypervariable regions are located in the tips of the Y, where they detect and bind to foreign proteins, also known as antigens. The bottom ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could ...

To take one example, antibody proteins fold into shapes ... and ultimately how life itself works. Determining a protein’s three-dimensional structure based solely on its one-dimensional amino ...

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell.

From left, Florida State University faculty researcher Fanny C. Liu and Christian Bleiholder, a professor in the Department ...