The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.

With spironolactone (Aldactone) treatment for acne rising several-fold in recent decades, safety concerns persist for this off-label practice in understudied populations. A database of U.S. insurance ...

Spironolactone is a diuretic (water pill) commonly used to treat heart failure and high blood pressure, but it can also be ...

Aldactone (spironolactone) is the most commonly used anti-androgen in the United States. It is a type of steroid that not only works as a testosterone blocker but is also used as a diuretic ...

Spironolactone oral tablet is a generic drug prescribed for heart failure, high blood pressure, and other conditions in adults. It is available as the brand-name drug Aldactone. An interaction ...

Objectives: This study was designed to investigate the appropriateness and complications of the use of spironolactone for heart failure (HF) in clinical practice. Background: Spironolactone was ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...