We have been exploring the potential of the neuromodulator, adenosine, to reduce excessive dopamine signaling that contributes to the development and persistence of psychostimulant abuse. Dopamine’s ...

The authors conclude that nonsynaptic release of ATP and subsequent activation of adenosine A 1 receptors contributes to suppression of thalamic activity and tremor, alone and during DBS ...

Oxford, UK-based Exscientia has been working with German biotech Evotec on the adenosine A2a receptor antagonist, which is being tested as a treatment for adult patients with advanced solid tumours.

Introduction It has been shown that caffeine promotes vigilance, attention, mood and arousal 5. The potential mechanisms of caffeine’s action include its role as an adenosine receptor antagonist that ...

a drug in the adenosine A2A receptor antagonist class. The Japanese drugmaker said (PDF) the decision wasn’t taken for clinical reasons, as trials suggested the drug had potential as a ...

It can penetrate the blood-brain barrier and act as an adenosine receptor antagonist, potentially boosting mood and enhancing ...