Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

AMP-activated protein kinase (AMPK) regulates metabolism by sensing changes in the AMP:ATP ratio in eukaryotic cells. The binding of AMP to AMPK and activation of its Ser/Thr protein-kinase domain ...

Despite its potential, developing selective activators of specific AMPK isoforms has remained technically challenging, with previous attempts to effectively drug the target proving unsuccessful.