The bicyclam AMD3100 is a well-known small molecule CXCR4 antagonist that strongly and specifically inhibits X4 HIV-1 infection. Tetrahydroquinoline-based AMD070 is a potent and specific X4 HIV-1 ...

Compounds targeting CXCR4, like AnorMed's (Langley, BC, Canada; now part of Genzyme) small molecules AMD3100 or AMD070, were successfully applied in cell culture experiments, but clinical studies ...

These sites bind to coreceptor CCR5 or CXCR4 on the membrane of the host cell (center panel), an event that initiates steps that culminate in the fusion of the HIV envelope with the host cell ...

Tumor slice cultures (TSCs) from five patients were treated with IgG1 isotype control, AMD3100 (AMD, a small molecule inhibitor of CXCR4), and anti-PD-1 T cell receptors (TCRs) play critical roles in ...